Naltraxone and Oxycodone

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SoloCPhT
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 Another medication that is

 Another medication that is being looked at to curb hyperanalgesia, increase effectiveness and has been touted as effective by users of Rx opioids for sometime is dextromethorphan. I do believe there is atleast one paper written on this and possiblely a clinical trial either in effect or "completed".

 Back to naltrexone, another good thing about the addition of naltrexone is that it significantly reduces constipation when co-administered with oxycodone. There are current and completed clinical trials studying the effects of oxycodone with naloxone on reducing constipation as well.

Ivy
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Is it true that naltrexone

Is it true that naltrexone blocks the pleasure center, and if so, how might this affect the patient in other areas of their life. I am not referring to the euphoric side effects of opiates in my questioning but rather, is it possible that this chemical has the potential to steal away other happiness from us in other ways as ackack mentioned?

Nevermind.

celticgreenman
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Naltrexone

Kathleen55,

The simple answer to your question ("Is the addition of this drug in the oxycodone formula designed to get rid of the "euphoria" that is sometimes experienced when taking this med?  Is that the "deterent" that folks are speaking of") is NO.

Euphoria is a subjective feeling.  Where one person may feel euphoric upon taking a medication, another may actually experience dysphoria (an unpleasant feeling). 

What medic008 stated about the oxycodone/Naltrexone combination is correct.  In this combination, it is not being used as a deterrent.  it is being added as an adjunct.

In Embeda, the Naltrexone is contained within tiny coated pellets.  If taken correctly, the pellets pass through.  If the pellets are crushed the Naltrexone is available to be absorbed through the gastric mucosa or through the blood-brain barrier (if injected).  It then works as the opioid antagonist that it is and will compete for the opioid receptors with any opioid agonist that's hanging around.  This will block the effects of opioid agonists (morphine, oxycodone, hydrocodone, codeine, etc) and may precipitate withdrawl symptoms.

This is oppossed to Naloxone, which is not absorbed through the gastic mucosa.  So, in Suboxone, when the Naloxone is swallowed, it passed through without being active.  It is added, to be a deterrent, to the Suboxone being injected.

cgm

 

Kathleen55
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Thanks

OK, now I understand!  Thanks to all who posted - you guys are geniuses in my book and the reason why I've asked my questions on this Board as opposed to some others.  Kath

guineapiggy500Troll
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I'm on Oxy/neltrexone

I am in this study, they are working fine, However, the milgram they have me on is not controlling my pain like I need it to. I believe once I am on the right dose it will be fine. I am surprised also that they do pretty much last a good 9-10 hours. I have seen the same Doctor for years he saved my life and I totaly trust him. He advised me it has been tested for a few years and is being used overseas with a reduction rate in abuse and illegal sales on the street. I am getting Free meds for a year, and since I use my meds for pain control like they are supposed to be seems like it is helping all involved.

Peace

Relapse_Rollerc...
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I was in the study

I found the drug to be just as affective without any change in the euphoric effects. Also no constipation, went everyday like clockwork. You can't even bite them in half, if you do anything to instantly release the oxy it will be counteracted. I did not experience any withdrawl. Also the formulation is 1/2 mg of narcan per mg of oc...ie- 40/20, 60/30, 20/10.

celticgreenman
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Relapse_Rollarcoaster, It is

Relapse_Rollarcoaster,

It is interesting that you were in a trial of a new formulation, that has an abuse deterent within it. But, were you in the study as part of the saftey phase, effects phase, or effectiveness phase? They are all actually done for separate reasons.

You speak of the euphoric effects not being diminished. But, how about the pain relief effects?

I could give a flying fig about being euphoric, I want pain relief.

cgm

Relapse_Rollerc...
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I said first that there was

I said first that there was no difference in the pain reliefe. That was what I meant at least. I was in the discovery phase. I never made it to the double blind because of course I had poor compliance. My post was meant to let people know that I am someone who has taken alot of pain meds and this one worked just as well as regular oxy. The only difference is u can do nothing to try to instant release or it will not work. Sorry if u misunderstood.

quincy
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Good News . . .

Hiya Relapse,

Thx for the scoop on the new OxyContin formulation. I sure hope that Purdue isn't blowing smoke where the sun don't shine, again, but your info sounds plenty solid (nyuknyuk) to me. An opioid tablet like you described, ie; truly abuse proof, just might get the opioid haters off of the CP community's collective back. It sure would be nice to be able to hold your head up at the corner pharm. again, what say pholks?     Q

celticgreenman
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Oxycodone? mixed with naltrexone or nalaxone?

Quincy,

I don't think it is a new formulation of OxyContin® (by Purdue), that Relapse_Rollarcoaster is speaking about. But, yet another company's attempt to make oxycodone abuse resistent. (No medication can ever be made completely abuse proof.)

In the thread ' google "Oxecta" ' , RR2 stated:

New Oxy

It is not niacin that is gonna be in the med..... I just did a six month study on a new drug. It was OC mixed with Narcan. They are easily crushed with no gel but because its an analgesis mixed with an antagonist it makes it impossible to abuse. You cannot break the med in any way or the two ingredients counteract eachother. A good thing about the narcan is it somehow reacts in the GI tract and prevents the constipation that often comes with opioids. The medicine definately kills the pain if u don't manipulate the original form.

Edited to remove excess info

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I think the abbreviation OC was for oxycodone. Because RR2 posts in this thread (#16 above) in response to oxycodone being mixed with naltrexone. RR2 does say that the study he/she took part in, the OC (oxycodone?) was mixed with Narcan (nalaxone) (the google "Oxecta" post). So, it is a little confusing that he/she is referring to two different medicines.

It would be nice to know what company was doing the research, and exactly what was in the medication (nalaxone or naltrexone).

cgm